Protein Details: Glutamate receptor 2.5

Protein ID

ICDB_Pro_1554

Protein Name

Glutamate receptor 2.5

Gene Name

GLR2.5; At5g11210; F2I11_100

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

918 amino acids

AlphaFoldDB

AF-Q9LFN5-F1-model_v4.pdb

Function

Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.

Sequence

MSLFHHLVSRFLSLWLLIFLVFLVLSLGKSQKEALQVKVGIVLGSNVTLADLSLRAINMSLSEFYNTHNGFKTRIVLNVRDSKQTVVGAAASALYLIKKREVVAIIGPGTSMQAPFLINLGNQSKVPIISFSATSPLLDSLRSPYFIRATHDDSSQVQAISAIIESFRWREVVPIYVDNEFGEGILPNLVDAFQEINVRIRYRSAISLHYSDDQIKKELYKLMTMPTRVFIVHMLPDLGSRLFSIAKEIDMLSKGYVWIVTNGIADLMSIMGESSLVNMHGVLGVKTYFAKSKELLHLEARWQKRFGGEELNNFACWAYDAATALAMSVEEIRHVNMSFNTTKEDTSRDDIGTDLDELGVALSGPKLLDALSTVSFKGVAGRFQLKNGKLEATTFKIINIEESGERTVGFWKSKVGLVKSLRVDKVSHSSRRLRPIIWPGDTIFVPKGWEFPTNAKKLRIAVPKKDGFNNFVEVTKDENTNVPTVTGFCIDVFNTVMSQMPYAVSYEYIPFDTPDGKPRGSYDEMVYNVFLGEFDGAVGDTTILANRSHYVDFALPYSETGIVFLVPVKDGKEKGEWVFLKPLTKELWLVTAASFLYIGIMVWIFEYQADEEFREQMIIDKISSVFYFSFSTLFFAHRRPSESFFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDDLRKSGVNIGYQTGSFTFERLKQMRFDESRLKTYNSPEEMRELFLHKSSNGGIDAAFDEVAYIKLFMAKYCSEYSIIEPTFKADGFGFAFPLGSPLVSDISRQILNITEGDAMKAIENKWFLGEKHCLDSTTSDSPIQLDHHSFEALFLIVFVVSVILLLLMLASRGYQERQHNASPNLPNDQANAAQEEVNEEGNVGDHIVEVDTALVRRKKLTSNTIPIRRVAPLSRLKSA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed predominantly in roots

DOI ID

10.1038/35048507; 10.1111/tpj.13415; 10.1126/science.292.5521.1486b; 10.1093/oxfordjournals.molbev.a004165

RefSeq

NP_001332219.1